Dr Mark Williams
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Overview
Overview
Highlights
A collaboration with Christine Orengo's lab, reveals the physical constraints on evolutionary adaptation in RubisCO, the enzyme that fixes CO2 in plants.
We are part of MOSBRI - the new European infrastructure for molecular-scale biophysics funded by Horizon2020 and dedicated to improving access to, and standards of, measurements of biomolecular function.
Our analysis on the controversial topic of enthalpy-entropy compensation shows, for the first time, how the extent of compensation varies from system to system
A collaboration with scientists at the Institute of Cancer Research identifies the Destruction Box receptor, which regulates chromosome separation during cell division
Web profiles
Professional memberships
Fellow of the Higher Education Academy
ORCID
0000-0002-1645-2189 -
Research
Research
Research interests
- Biolmolecular Stucture and Thermodynamics
- Protein-Protein Interactions
- Protein Structure
- Bacterial Cell Division
- Methods for Biomolecular Interaction Measurement
- Molecular Simulation Methods and Applications
Research overview
Research in my group aims to apply a multi-disciplinary approach using biophysical and structural experimental methods, structural bioinformatic analysis and physics-based molecular simulation to develop an integrated understanding of the formation of biomolecular complexes. In addition to working on specific biological systems, e.g. in bacterial cell division, we are developing methods for measurement, data analysis and simulation of interactions.
Research Centres and Institutes
- Director of ISMB BiophysX, Institute of Structural Molecular Biology (ISMB)
Research clusters and groups
- Leader of WP3 - Standards in Biophysics, MOSBRI
- co-Leader WP4 Data Standards and Exploitation, MOSBRI
Research projects
MOlecular-Scale Biophysics Research Infrastructure.
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Supervision and teaching
Supervision and teaching
Supervision
Students interested in joining the group for PhD research should usually apply through the doctoral training programmes in which the ISMB is involved.
Current doctoral researchers
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RACHEL ALCRAFT
Teaching
I am Programme Director for the MRes in Bioinformatics and my principle teaching duties are related to core modules of the MSc and MRes Bioinformatics.
Teaching modules
- Specialist Laboratory Research Project (SCBS036D6)
- Statistics and Data Science (SCBS087S7)
- The Molecular Basis of Life (SCBS095S7)
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Publications
Publications
Article
- Muselmani, Wael and Kashif-Khan, Naail and Bagneris, Claire and Santangelo, Rosalia and Williams, Mark A and Savva, Renos (2023) A multimodal approach towards genomic identification of protein inhibitors of Uracil-DNA Glycosylase. Viruses 15 (6), ISSN 1999-4915.
- Lopez-Mendes, B. and Baron, B. and Brautigam, C.A. and Jowitt, T.A. and Knauer, S.H. and Uebel, S. and Williams, Mark and Sedivy, A. (2021) Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study. European Biophysics Journal with Biophysics letters 50, pp. 411-427. ISSN 0175-7571.
- Paketurytė, V. and Petrauskas, V. and Zubrienė, A. and Abian, O. and Bastos, M. and Chen, W.-Y. and Moreno, M.J. and Krainer, G. and Linkuvienė, V. and Sedivy, A. and Velazquez-Campoy, A. and Williams, Mark A. and Matulis, D. (2021) Uncertainty of protein-ligand binding constants: asymmetric confidence intervals versus standard errors. European Biophysics Journal with Biophysics letters 50, pp. 661-670. ISSN 0175-7571.
- Sivalingam, G.N. and Cryar, A. and Williams, Mark A. and Gooptu, Bibekbrata and Thalassinos, Konstantinos (2018) Deconvolution of ion mobility mass spectrometry arrival time distributions using a genetic algorithm approach: application to α1-antitrypsin peptide binding. International Journal of Mass Spectrometry 426, pp. 29-37. ISSN 1387-3806.
- Studer, R. A. and Christin, P.-A. and Williams, Mark A. and Orengo, C.A. (2014) Stability-activity tradeoffs constrain the adaptive evolution of RubisCO. Proceedings of the National Academy of Sciences of the United States of America 111 (6), pp. 2223-2228. ISSN 0027-8424.
- Olsson, T.S.G. and Pitt, W.R. and Ladbury, J.E. and Williams, Mark A. (2011) The extent of enthalpy-entropy compensation in protein-ligand interactions. Protein Science 20 (9), pp. 1607-1618. ISSN 0961-8368.
- da Fonsceca, P.C.A. and Kong, E.H. and Zhang, Z. and Schreiber, A. and Williams, Mark A. and Morris, E.P. and Barford, D. (2011) Structures of APC/C-CDH1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor. Nature 470, pp. 274-278. ISSN 0028-0836.
- Nilapwar, S. and Smith, E.P. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) Structural-thermodynamics relationships of interactions in the N-terminal ATP binding domain of Hsp90. Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.
- Nilapwar, S. and Williams, E. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) Structural–thermodynamic relationships of interactions in the N-Terminal ATP-Binding domain of Hsp90. Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.
- Olsson, T.S.G. and Williams, Mark A. and Pitt, W.R. and Ladbury, J.E. (2008) The thermodynamics of protein–ligand interaction and solvation: insights for ligand design. Journal of Molecular Biology 384 (4), pp. 1002-1017. ISSN 0022-2836.
Book Section
- Williams, Mark A. (2017) Apparent equilibrium thermodynamics of protein-ligand binding reactions. In: Lide, D.R. (ed.) CRC Handbook of Chemistry and Physics, 98th Edition. Florida, U.S.: CRC Press. ISBN 9781498784542.
- Daviter, Tina and Chmel, N. and Rodger, A. (2013) Circular and linear dichroism spectroscopy for the study of protein–ligand interactions. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 211-241. ISSN 1940-6029. ISBN 9781627033978.
- Daviter, Tina and Fronzes, Remi (2013) Protein sample characterization. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 35-62. ISSN 1940-6029. ISBN 9781627033978.
- Lowe, P.N. and Vaughan, Cara K. and Daviter, Tina (2013) Measurement of protein–ligand complex formation. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 63-99. ISSN 1940-6029. ISBN 9781627033978.
- Turnbull, Andrew P. and Emsley, P. (2013) Studying protein–ligand interactions using x-ray crystallography. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 457-477. ISSN 1940-6029. ISBN 9781627033978.
- Williams, Mark A. (2013) Protein-ligand interactions: fundamentals. In: Williams, Mark A. and Daviter, Tina (eds.) Protein–Ligand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 3-34. ISSN 1940-6029. ISBN 9781627033978.
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Business and community
Business and community
Outreach
Rosalind Franklin Centenary celebrations - Why is Rosalind Franklin a hero in structural biology?
LIDo Outreach - widening participation in PhD study
Services
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Other
01-JUL-21 to 30-JUN-25
Collaborative research on software development for biomolecular interaction analysis with Affinimeter (Software4Science S.A.)
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Other