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Info
Positions held:
Professor of Structural Molecular Biology,
School of Natural Sciences
Supervision and teaching
Supervision and teaching
Teaching
Teaching modules
Molecular Biology for Discovery Life Sciences (SCBS096S7)
Publications
Publications
Article
Mace, Kevin and Meir, A. and Lukoyanova, Natalya and Liu, L. and Chetrit, D. and Hospenthal, M.K. and Roy, C.R. and Waksman, Gabriel
(2022)
Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila .
Molecular Microbiology
117
(2),
pp. 307-319.
ISSN 0950-382X.
Meir, A. and Macé, K. and Lukoyanova, N. and Chetrit, D. and Hospenthal, M.K. and Redzej, A. and Roy, C. and Waksman, Gabriel
(2020)
Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila .
Nature Communications
11
(1),
ISSN 2041-1723.
Williams, A.H. and Redzej, Adam and Rolhion, N. and Costa, Tiago R.D. and Rifflet, A. and Waksman, Gabriel and Cossart, P.
(2019)
The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation .
Nature Communications
10
(1),
pp. 3005.
ISSN 2041-1723.
Hospenthal, M.K. and Waksman, Gabriel
(2019)
The remarkable biomechanical properties of the Type 1 Chaperone-Usher Pilus: a structural and molecular perspective .
Microbiology Spectrum
7
(1),
ISSN 2165-0497.
Waksman, Gabriel
(2019)
From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective .
EMBO Reports
20
(2),
pp. e47012.
ISSN 1469-3178.
Sgro, G.G. and Costa, Tiago and Cenens, W. and Souza, D.P. and Cassago, A. and Coutinho de Oliveira, L. and Salinas, R.K. and Portugal, R.V. and Farah, C.S. and Waksman, Gabriel
(2018)
Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri .
Nature Microbiology
3
(12),
pp. 1429-1440.
ISSN 2058-5276.
Prevost, Marie S. and Waksman, Gabriel
(2018)
X-ray crystal structures of the Type IVb Secretion System DotB ATPases .
Protein Science
27
(8),
pp. 1464-1475.
ISSN 0961-8368.
Galán, J.E. and Waksman, Gabriel
(2018)
Protein-injection machines in bacteria .
Cell
172
(6),
pp. 1306-1318.
ISSN 0092-8674.
Trokter, Martina and Waksman, Gabriel
(2018)
Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate .
Journal of Bacteriology
200
(20),
ISSN 0021-9193.
Trokter, Martina and Waksman, Gabriel
(2018)
Translocation through the conjugative Type 4 secretion system requires unfolding of its protein substrate .
Journal of Bacteriology
200
(6),
pp. JB.00615-17.
ISSN 0021-9193.
Meir, A. and Chetrit, D. and Liu, L. and Roy, C. and Waksman, Gabriel
(2018)
Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system .
Nature Communications
9,
pp. 507.
ISSN 2041-1723.
Grohmann, E. and Christie, P.J. and Waksman, Gabriel and Backert, S.
(2017)
Type IV secretion in Gram-negative and Gram-positive bacteria .
Molecular Microbiology
107
(4),
pp. 455-471.
ISSN 0950-382X.
Pinotsis, Nikos and Waksman, Gabriel
(2017)
Crystal structure of the Legionella pneumophila Lpg2936 in complex with the cofactor S-adenosyl-L-methionine reveals novel insights into the mechanism of RsmE family methyltransferases .
Protein Science
26
(12),
pp. 2381-2391.
ISSN 0961-8368.
Redzej, Adam and Ukleja, Marta and Connery, Sarah and Trokter, Martina and Felisberto‐Rodrigues, Catarina and Cryar, A. and Thalassinos, Konstantinos and Hayward, Richard D. and Orlova, Elena V. and Waksman, Gabriel
(2017)
Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery .
The EMBO Journal
36
(19),
pp. e201796629.
ISSN 0261-4189.
Prevost, Marie S. and Pinotsis, Nikos and Dumoux, Maud and Hayward, Richard D. and Waksman, Gabriel
(2017)
The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery .
Scientific Reports
7
(1),
ISSN 2045-2322.
Waksman, Gabriel
(2017)
Structural and molecular biology of a protein-polymerizing nanomachine for pilus biogenesis .
Journal of Molecular Biology
429
(17),
pp. 2654-2666.
ISSN 0022-2836.
Gordon, J.E. and Costa, Tiago and Patel, R.S. and Gonzalez-Rivera, C. and Sarkar, M.K. and Orlova, Elena and Waksman, Gabriel and Christie, P.J.
(2017)
Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation .
Molecular Microbiology
105
(2),
pp. 273-293.
ISSN 0950-382X.
Goosens, V.J. and Busch, Andreas and Georgiadou, M. and Castagnini, M. and Forest, K.T. and Waksman, Gabriel and Pelicic, V.
(2017)
Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili .
Proceedings of the National Academy of Sciences of the United States of America
114
(25),
pp. E4978-E4986.
ISSN 0027-8424.
Pinotsis, Nikos and Waksman, Gabriel
(2017)
Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila .
Journal of Biological Chemistry
292
(22),
pp. 9240-9251.
ISSN 0021-9258.
Ilangovan, A. and Kay, C.W.M. and Roier, S. and El Mkami, H. and Salvadori, E. and Zechner, E.L. and Zanetti, Giulia and Waksman, Gabriel
(2017)
Cryo-EM structure of a relaxase reveals the molecular basis of DNA unwinding during bacterial conjugation .
Cell
169
(4),
pp. 708-721.e12.
ISSN 0092-8674.
Hospenthal, M.K. and Costa, Tiago and Waksman, Gabriel
(2017)
Pilus biogenesis at the inner and outer membranes of Gram-negative bacteria .
Nature Reviews Microbiology
15,
pp. 365-379.
ISSN 1740-1526.
Hospenthal, M.K. and Costa, Tiago and Waksman, Gabriel
(2017)
A comprehensive guide to pilus biogenesis in Gram-negative bacteria .
Nature Reviews Microbiology
15
(6),
pp. 365-379.
ISSN 1740-1526.
Hospenthal, Manuela K. and Zyla, D. and Costa, Tiago R.D. and Redzej, Adam and Giese, C. and Lillington, James and Glockshuber, R. and Waksman, Gabriel
(2017)
The Cryoelectron Microscopy structure of the Type 1 Chaperone-Usher Pilus Rod .
Structure
25
(12),
pp. 1829-1838.e4.
ISSN 0969-2126.
Costa, Tiago and Ilangovan, Aravindan and Ukleja, Marta and Redzej, Adam and Santini, Joanne and Smith, T.K. and Egelman, E.H. and Waksman, Gabriel
(2016)
Structure of the Bacterial Sex F Pilus reveals an assembly of a Stoichiometric Protein-Phospholipid Complex .
Cell
166
(6),
pp. 1436-1444.e10.
ISSN 0092-8674.
Stubenrauch, C. and Belousoff, M.J. and Hay, I.D. and Shen, H.-H. and Lillington, James and Tuck, K.L. and Peters, K.M. and Phan, M.-D. and Lo, A.W. and Schembri, M.A. and Strugnell, R.A. and Waksman, Gabriel and Lithgow, T.
(2016)
Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine .
Nature Microbiology
1
(7),
pp. 16064.
ISSN 2058-5276.
Papaioannou, D. and Geibel, S. and Kunze, M.B.A. and Kay, C.W.M. and Waksman, Gabriel
(2016)
Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide .
Protein Science
25
(3),
pp. 627-637.
ISSN 0961-8368.
Hospenthal, M.K. and Redzej, A. and Dodson, K. and Ukleja, M. and Frenz, B. and Rodrigues, C. and Hultgren, S.J. and DiMaio, F. and Egelman, E.H. and Waksman, Gabriel
(2016)
Structure of a Chaperone-Usher Pilus reveals the molecular basis of rod uncoiling .
Cell
164,
pp. 269-278.
ISSN 0092-8674.
Ruer, S. and Pinotsis, Nikos and Steadman, D. and Waksman, Gabriel and Remaut, H.
(2015)
Virulence-targeted antibacterials: concept, promise, and susceptibility to resistance mechanisms .
Chemical Biology & Drug Design
86
(4),
pp. 379-399.
ISSN 1747-0277.
Kaplan, M. and Cukkemane, A. and van Zundert, G.C.P and Narasimhan, S. and Daniëls, M. and Mance, D. and Waksman, Gabriel and Bonvin, A.M.J.J and Fronzes, R. and Folkers, G.E. and Baldus, M.
(2015)
Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR .
Nature Methods
12
(7),
pp. 649-652.
ISSN 1548-7091.
Chandran Darbari, V. and Waksman, Gabriel
(2015)
Structural biology of bacterial Type IV secretion systems .
Annual Review of Biochemistry
84
(1),
pp. 603-629.
ISSN 0066-4154.
Dias da Costa, Tiago and Felisberto-Rodrigues, Catarina and Meir, A. and Prevost, M.S. and Redzej, Adam and Trokter, Martina and Waksman, Gabriel
(2015)
Secretion systems in Gram-negative bacteria: structural and mechanistic insights .
Nature Reviews Microbiology
13
(6),
pp. 343-359.
ISSN 1740-1526.
Garnett, J.A. and Muhl, D. and Douse, C.H. and Hui, K. and Busch, Andreas and Omisore, A. and Yang, Y. and Simpson, P. and Marchant, J. and Waksman, Gabriel and Matthews, S. and Filloux, A.
(2015)
Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation .
Protein Science
24
(5),
pp. 670-687.
ISSN 0961-8368.
Ilangovan, Aravindan and Connery, Sarah and Waksman, Gabriel
(2015)
Structural biology of the Gram-negative bacterial conjugation systems .
Trends in Microbiology
23
(5),
pp. 301-310.
ISSN 0966-842X.
Busch, A. and Phan, G. and Waksman, Gabriel
(2015)
Molecular mechanism of bacterial type 1 and P pili assembly .
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
373
(2037),
pp. 20130153-20130153.
ISSN 1364-503X.
Redzej, Adam and Waksman, Gabriel and Orlova, Elena
(2015)
Structural studies of T4S systems by electron microscopy .
AIMS Biophysics
2
(2),
pp. 184-199.
ISSN 2377-9098.
Sayer, J.R. and Walldén, Karin and Pesnot, T. and Campbell, F. and Gane, P.J. and Simone, M. and Koss, H. and Buelens, Floris and Boyle, T.P. and Selwood, D.L. and Waksman, Gabriel and Tabor, A.B.
(2014)
2- and 3-substituted imidazo [1,2-a] pyrazines as inhibitors of bacterial type IV secretion .
Bioorganic & Medicinal Chemistry
22
(22),
pp. 6459-6470.
ISSN 0968-0896.
Farabella, Irene and Pham, T. and Henderson, N.S. and Geibel, Sebastien and Phan, Gilles and Thanassi, D.G. and Delcour, A.H. and Waksman, Gabriel and Topf, Maya
(2014)
Allosteric signalling in the outer membrane translocation domain of PapC usher .
eLife
3,
ISSN 2050-084X.
Gonen, T. and Waksman, Gabriel
(2014)
Editorial overview - Membranes: recent methods in the study of membrane protein structure .
Current Opinion in Structural Biology
27,
pp. iv-v.
ISSN 0959-440X.
Lillington, J. and Geibel, Sebastien and Waksman, Gabriel
(2014)
Biogenesis and adhesion of type 1 and P pili .
Biochimica et Biophysica Acta (BBA) - General Subjects
1840
(9),
pp. 2783-2793.
ISSN 0304-4165.
Geibel, Sebastien and Waksman, Gabriel
(2014)
The molecular dissection of the Chaperone-Usher Pathway .
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
1843
(8),
pp. 1559-1567.
ISSN 0167-4889.
Trokter, Martina and Felisberto-Rodrigues, Catarina and Christie, P.J. and Waksman, Gabriel
(2014)
Recent advances in the structural and molecular biology of type IV secretion systems .
Current Opinion in Structural Biology
27,
pp. 16-23.
ISSN 0959-440X.
Low, Harry H. and Gubellini, Francesca and Rivera-Calzada, Angel and Braun, Nathalie and Connery, Sarah and Dujeancourt, A. and Lu, Fang and Redzej, Adam and Fronzes, R. and Orlova, Elena and Waksman, Gabriel
(2014)
Structure of a type IV secretion system .
Nature
508,
pp. 550-553.
ISSN 0028-0836.
Waksman, Gabriel and Orlova, Elena
(2014)
Structural organisation of the type IV secretion systems .
Current Opinion in Microbiology
17,
pp. 24-31.
ISSN 1369-5274.
Steadman, David and Lo, A. and Waksman, Gabriel and Remaut, H.
(2014)
Bacterial surface appendages as targets for novel antibacterial therapeutics .
Future Microbiology
9
(7),
pp. 887-900.
ISSN 1746-0913.
Redzej, Adam and Ilangovan, Aravindan and Lang, S. and Gruber, C.J. and Topf, Maya and Zangger, K. and Zechner, E.L. and Waksman, Gabriel
(2013)
Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems .
Molecular Microbiology
89
(2),
pp. 324-333.
ISSN 0950-382X.
Lillington, James and Waksman, Gabriel
(2013)
Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili .
Biology
2
(3),
pp. 841-860.
ISSN 2079-7737.
Rivera-Calzada, A. and Fronzes, Remi and Savva, Christos G. and Chandran, Vidya and Lian, Pei W. and Laeremans, T. and Pardon, E. and Steyaert, J. and Remaut, Han and Waksman, Gabriel and Orlova, Elena
(2013)
Structure of a bacterial type IV secretion core complex at subnanometre resolution .
The EMBO Journal
32
(8),
pp. 1195-1204.
ISSN 1460-4189.
Geibel, Sebastien and Procko, E. and Hultgren, S.J. and Baker, D. and Waksman, Gabriel
(2013)
Structural and energetic basis of folded-protein transport by the FimD usher .
Nature
496
(7444),
pp. 243-246.
ISSN 0028-0836.
Lo, A.W. and Van de Water, K. and Gane, P.J. and Chan, A.W. and Steadman, David and Stevens, Kiri and Selwood, D.L. and Waksman, Gabriel and Remaut, H.
Kogon, E., ed.
(2013)
Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization .
Journal of Antimicrobial Chemotherapy
69
(4),
pp. 1017-1026.
ISSN 1460-2091.
Allen, William J. and Phan, Gilles and Hultgren, S.J. and Waksman, Gabriel
(2013)
Dissection of pilus tip assembly by the FimD usher monomer .
Journal of Molecular Biology
425
(5),
pp. 958-967.
ISSN 0022-2836.
Lithgow, T. and Waksman, Gabriel
(2013)
Seaside transportation: from structure to function of translocation machines .
EMBO reports
14
(7),
pp. 585-587.
ISSN 1469-221X.
Rothwell, P.J. and Allen, W.J. and Sisamakis, E. and Kalinin, S. and Felekyan, S. and Widengren, J. and Waksman, Gabriel and Seidel, C.A.M.
(2013)
dNTP-dependent conformational transitions in the fingers subdomain of klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state .
Journal of Biological Chemistry
288
(19),
pp. 13575-13591.
ISSN 0021-9258.
Volkan, E. and Kalas, V. and Pinkner, J.S. and Dodson, K.W. and Henderson, N.S. and Pham, T. and Waksman, Gabriel and Delcour, A.H. and Thanassi, D.G. and Hultgren, S.J.
(2013)
Molecular basis of usher pore gating in Escherichia coli pilus biogenesis .
Proceedings of the National Academy of Sciences of the United States of America
110
(51),
pp. 20741-20746.
ISSN 0027-8424.
Toste-Rêgo, Ana and Johnson, J.G. and Geibel, Sebastien and Enguita, F.J. and Clegg, S. and Waksman, Gabriel
(2012)
Crystal structure of the MrkD1P receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface .
Molecular Microbiology
86
(4),
pp. 882-893.
ISSN 0950-382X.
Allen, William J. and Phan, Gilles and Waksman, Gabriel
(2012)
Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens .
Current Opinion in Structural Biology
22
(4),
pp. 500-506.
ISSN 0959-440X.
Gonen, T. and Waksman, Gabriel
(2012)
Recent progress in membrane protein structures and investigation methods .
Current Opinion in Structural Biology
22
(4),
pp. 467-468.
ISSN 0959-440X.
Walldén, Karin and Williams, Robert and Yan, Jun and Lian, Pei W. and Wang, Luchun and Thalassinos, Konstantinos and Orlova, Elena and Waksman, Gabriel
(2012)
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system .
Proceedings of the National Academy of Sciences of the United States of America
109
(28),
pp. 11348-11353.
ISSN 0027-8424.
Waksman, Gabriel
(2012)
Bacterial secretion comes of age .
Philosophical Transactions of the Royal Society B: Biological Sciences
367
(1592),
pp. 1014-1015.
ISSN 0962-8436.
Busch, Andreas and Waksman, Gabriel
(2012)
Chaperone-usher pathways: diversity and pilus assembly mechanism .
Philosophical Transactions of the Royal Society B: Biological Sciences
367
(1592),
pp. 1112-1122.
ISSN 0962-8436.
Ford, B. and Verger, D. and Dodson, K. and Volkan, E. and Kostakioti, M. and Elam, J. and Pinkner, J. and Waksman, Gabriel and Hultgren, S.
(2012)
The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket .
Journal of Bacteriology
194
(23),
pp. 6390-6397.
ISSN 0021-9193.
Morrissey, B. and Leney, A.C. and Toste Rego, A. and Phan, G. and Allen, W.J. and Verger, D. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E.
(2012)
The role of chaperone-subunit usher domain interactions in the mechanism of bacterial pilus biogenesis revealed by ESI-MS .
Molecular & Cellular Proteomics
11
(7),
ISSN 1535-9476.
Volkan, E. and Ford, B.A. and Pinkner, J.S. and Dodson, K.W. and Henderson, N.S. and Thanassi, D.G. and Waksman, Gabriel and Hultgren, S.J.
(2012)
Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine .
Proceedings of the National Academy of Sciences of the United States of America
109
(24),
pp. 9563-9568.
ISSN 0027-8424.
Jiaa, H. and Korolev, S. and Niedziela-Majkaa, A. and Malufa, N.K. and Gaussa, G.H. and Myongf, S. and Hag, T. and Waksman, Gabriel and Lohman, T.M.
(2011)
Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding .
Journal of Molecular Biology
411
(3),
pp. 633-648.
ISSN 0022-2836.
Leney, A.C. and Phan, Gilles and Allen, William J. and Verger, Denis and Waksman, Gabriel and Radford, S.E. and Ashcroft, A.E.
(2011)
Second order rate constants of donor-strand exchange reveal individual amino acid residues important in determining the subunit specificity of Pilus Biogenesis .
Journal of The American Society for Mass Spectrometry
22
(7),
pp. 1214-1223.
ISSN 1044-0305.
Banta, L.M. and Kerr, J.E. and Cascales, E. and Giuliano, M.E. and Bailey, M.E. and McKay, C. and Chandran, Vidya and Waksman, Gabriel and Christie, P.J.
(2011)
An Agrobacterium VirB10 Mutation Conferring a Type IV Secretion System Gating Defect .
Journal of Bacteriology
193
(10),
pp. 2566-2574.
ISSN 0021-9193.
Terradot, L. and Waksman, Gabriel
(2011)
Architecture of the Helicobacter pylori Cag-type IV secretion system .
FEBS Journal
278
(8),
pp. 1213-22.
ISSN 1742-464X.
Lemaître, G. and Stella, A. and Feteira, J. and Baldeschi, C. and Vaigot, P. and Martin, M.T. and Monsarrat, B. and Waksman, Gabriel
(2011)
CD98hc (SLC3A2) is a key regulator of keratinocyte adhesion .
Journal of Dermatological Science
61
(3),
pp. 169-179.
ISSN 0923-1811.
Cai, X. and Wang, R. and Filloux, A. and Waksman, Gabriel and Meng, G.Y.
(2011)
Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones .
PLoS One
6
(1),
ISSN 1932-6203.
Chudasama, V. and Smith, M.E.B. and Schumacher, F.F. and Papaioannou, D. and Waksman, Gabriel and Baker, J.R. and Caddick, S.
(2011)
Bromopyridazinedione-mediated protein and peptide bioconjugation .
Chemical Communications
47
(31),
pp. 8781-8783.
ISSN 1359-7345.
Durand, E. and Waksman, Gabriel and Receveur-Brechot, V.
(2011)
Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system .
BMC Structural Biology
11
(4),
ISSN 1472-6807.
Geibel, Sebastien and Waksman, Gabriel
(2011)
Crystallography and electron microscopy of chaperone/usher pilus systems .
Advances In Experimental Medicine & Biology
715,
pp. 159-174.
ISSN 0065-2598.
Meng, G. and Spahich, N. and Kenjale, R. and Waksman, Gabriel and St Geme, J.W.
(2011)
Crystal structure of the haemophilus influenzae hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation .
The EMBO Journal
30
(18),
pp. 3663-3874.
ISSN 0261-4189.
Phan, Gilles and Remaut, Han and Wang, T. and Allen, William J. and Pirker, Katharina F. and Lebedev, A. and Henderson, N.S. and Geibel, Sebastien and Volkan, E. and Yan, Jun and Kunze, M.B.A. and Pinkner, J.S. and Ford, B. and Kay, Christopher W.M. and Li, H.L. and Hultgren, S.J. and Thanassi, D.G. and Waksman, Gabriel
(2011)
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate .
Nature
474
(7349),
pp. 49-53.
ISSN 0028-0836.
Ryan, C.P. and Smith, M.E.B. and Schumacher, F.F. and Grohmann, D. and Papaioannou, D. and Waksman, Gabriel and Werner, F. and Baker, J.R. and Caddick, S.
(2011)
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis .
Chemical Communications
47
(19),
pp. 5452-5454.
ISSN 1359-7345.
Van Gerven, N. and Waksman, Gabriel and Remaut, H.
(2011)
Pili and flagella biology, structure, and biotechnological applications .
Progress in Molecular Biology and Translational Science
103,
pp. 21-72.
ISSN 1877-1173.
Walldén, Karin and Rivera-Calzada, A. and Waksman, Gabriel
(2010)
Microreview: type IV secretion systems: versatility and diversity in function .
Cellular Microbiology
12
(9),
pp. 1203-1212.
ISSN 1462-5814.
Walldén, Karin and Rivera-Calzada, A. and Waksman, Gabriel
(2010)
Type IV secretion systems: versatility and diversity in function .
Cellular Microbiology
12
(9),
pp. 1203-1212.
ISSN 1462-5814.
Chorell, E. and Pinkner, J.S. and Phan, Gilles and Edvinsson, S. and Buelens, Floris and Remaut, Han and Waksman, Gabriel and Hultgren, S.J. and Almqvist, F.
(2010)
Design and synthesis of C-2 substituted Thiazolo and Dihydrothiazolo ring-fused 2-Pyridones: Pilicides with increased antivirulence activity .
Journal of Medicinal Chemistry
53
(15),
pp. 5690-5695.
ISSN 0022-2623.
Waksman, Gabriel and Fronzes, Remi
(2010)
Molecular architecture of bacterial type IV secretion systems .
Trends in Biochemical Sciences
35
(12),
pp. 691-698.
ISSN 0968-0004.
Durand, E. and Oomen, C. and Waksman, Gabriel
(2010)
Biochemical dissection of the ATPase TraB, the VirB4 homologue of the Escherichia coli pKM101 conjugation machinery .
Journal of Bacteriology
192
(9),
pp. 2315-2323.
ISSN 0021-9193.
Ford, B. and Rego, A.T. and Ragan, T.J. and Pinkner, J.S. and Dodson, K. and Driscoll, P.C. and Hultgren, S.J. and Waksman, Gabriel
(2010)
Structural homology between the C-Terminal domain of the PapC usher and its plug .
Journal of Bacteriology
192
(7),
pp. 1824-1831.
ISSN 0021-9193.
Virdee, S. and Macmillan, D. and Waksman, Gabriel
(2010)
Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives .
Chemistry & Biology
17
(3),
pp. 274-284.
ISSN 1879-1301.
Rego, A.T. and Chandran, Vidya and Waksman, Gabriel
(2010)
Two-step and one-step secretion mechanisms in gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis .
Biochemical Journal
425,
pp. 475-488.
ISSN 0264-6021.
Smith, M.E.B. and Schumacher, F.F. and Ryan, C.P. and Tedaldi, L.M. and Papaioannou, D. and Waksman, Gabriel and Caddick, S. and Baker, J.R.
(2010)
Protein modification, bioconjugation, and disulfide bridging using Bromomaleimides .
Journal of the American Chemical Society
132
(6),
pp. 1960-1965.
ISSN 0002-7863.
Rego, A.T. and Fronzes, Remi and Waksman, Gabriel
(2010)
SnapShot: bacterial appendages II .
Cell
140
(2),
pp. 294-294.
ISSN 0092-8674.
Rego, A.T. and Fronzes, Remi and Waksman, Gabriel
(2010)
SnapShot: bacterial appendages I .
Cell
140
(1),
pp. 162-u163.
ISSN 0092-8674.
Chandran, Vidya and Duquerroy, S. and Cronin, Nora and Navaza, J. and Fronzes, Remi and Waksman, Gabriel
(2009)
Structure of the outer membrane complex of a type IV secretion system .
Nature
462
(7276),
pp. 1011-1015.
ISSN 0028-0836.
Durand, E. and Verger, Denis and Rego, A.T. and Chandran, Vidya and Meng, G.Y. and Fronzes, Remi and Waksman, Gabriel
(2009)
Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets .
Infectious Disorders - Drug Targets
9
(5),
pp. 518-847.
ISSN 1871-5265.
Hultgren, S.J. and Waksman, Gabriel
(2009)
Structural biology of the chaperone-usher pathway of pilus biogenesis .
Nature Reviews Microbiology
7,
pp. 765-774.
ISSN 1740-1526.
Kenjale, R. and Fink, D.L. and Juehne, T. and Ohashi, T. and Erickson, H.P. and Meng, G.Y. and Waksman, Gabriel and St. Geme, J.W.
(2009)
Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter .
Infection and Immunity
77
(11),
pp. 4704-4713.
ISSN 0019-9567.
Fronzes, Remi and Christie, P.J. and Waksman, Gabriel
(2009)
The structural biology of type IV secretion systems .
Nature Reviews Microbiology
7
(10),
pp. 703-714.
ISSN 1740-1526.
Radin, J.N. and Grass, S.A. and Meng, G.Y. and Cotter, S.E. and Waksman, Gabriel and St. Geme, J.W.
(2009)
Structural basis for the differential binding affinities of the HsfBD1 and HsfBD2 domains in the Haemophilus influenzae Hsf adhesin .
Journal of Bacteriology
191
(16),
pp. 5068-5075.
ISSN 0021-9193.
Waksman, Gabriel
(2009)
Going round in circles: the structural biology of type III secretion systems .
Nature Structural & Molecular Biology
16,
pp. 459-460.
ISSN 1545-9985.
Meng, G.Y. and Chandran, Vidya and Remaut, Han and Fronzes, Remi and Waksman, Gabriel
(2009)
Protein oligomerization in the bacterial outer membrane (Review) .
Molecular Membrane Biology
26
(3),
pp. 136-145.
ISSN 0968-7688.
Jakubowski, S.J. and Kerr, J.E. and Garza, I. and Krishnamoorthy, V. and Bayliss, R. and Waksman, Gabriel and Christie, P.J.
(2009)
Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis .
Molecular Microbiology
71
(3),
pp. 779-794.
ISSN 0950-382X.
Fronzes, Remi and Schafer, Eva and Wang, Luchun and Saibil, Helen R. and Orlova, Elena and Waksman, Gabriel
(2009)
Structure of a type IV secretion system core complex .
Science
323
(5911),
pp. 266-268.
ISSN 0036-8075.
Guenou, H. and Nissan, X. and Larcher, F. and Feteira, J. and Lemaître, G. and Saidani, M. and Del Rio, M. and Barrault, C.C. and Bernard, F.-X. and Peschanski, M. and Baldeschi, C. and Waksman, Gabriel
(2009)
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study .
The Lancet
374
(9703),
pp. 1745-1753.
ISSN 0140-6736.
Waksman, Gabriel and Hultgren, S.J.
(2009)
Structural biology of the chaperone–usher pathway of pilus biogenesis .
Nature Reviews Microbiology
7
(11),
pp. 765-774.
ISSN 1740-1526.
Waksman, Gabriel and Meng, G.Y. and St. Geme, J.W.
(2008)
Repetitive architecture of the Haemophilus influenzae hia trimeric autotransporter .
Journal of Molecular Biology
384
(4),
pp. 824-836.
ISSN 0022-2836.
Verger, Denis and Rose, R.J. and Paci, E. and Costakes, G. and Daviter, Tina and Hultgren, S.J. and Remaut, Han and Ashcroft, A.E. and Radford, S.E. and Waksman, Gabriel
(2008)
Structural determinants of polymerization reactivity of the P pilus Adaptor Subunit PapF .
Structure
16
(11),
pp. 1724-1731.
ISSN 0969-2126.
Backert, S. and Fronzes, Remi and Waksman, Gabriel
(2008)
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems? .
Trends in Microbiology
16
(9),
pp. 409-413.
ISSN 0966-842X.
Fronzes, Remi and Remaut, Han and Waksman, Gabriel
(2008)
Architectures and biogenesis of non-flagellar protein appendages in gram-negative bacteria .
Embo Journal
27
(17),
pp. 2271-2280.
ISSN 0261-4189.
Rose, R.J. and Verger, Denis and Daviter, Tina and Remaut, Han and Paci, E. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E.
(2008)
Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry .
Proceedings of the National Academy of Sciences of the United States of America
105
(35),
pp. 12873-12878.
ISSN 0027-8424.
de Fabritiis, G. and Geroult, S. and Coveney, P.V. and Waksman, Gabriel
(2008)
Insights from the energetics binding at the domain-ligand of the Src SH2 domain of water interface .
Proteins-Structure, Function and Bioinformatics
72
(4),
pp. 1290-1290.
ISSN 0887-3585.
Bagneris, Claire and Ageichik, A.V. and Cronin, Nora and Wallace, Bonnie A. and Collins, M. and Boshoff, C. and Waksman, Gabriel and Barrett, Tracey E.
(2008)
Crystal structure of a vFlip-IKKγ Complex: insights into viral activation of the IKK Signalosome .
Molecular Cell
30
(5),
pp. 620-631.
ISSN 1097-2765.
Bagneris, Claire and Ageichik, A.V. and Cronin, Nora and Wallace, Bonnie A. and Collins, M. and Boshoff, C. and Waksman, Gabriel and Barrett, Tracey E.
(2008)
Crystal structure of a vFlip-IKK gamma complex: Insights into viral activation of the IKK signalosome .
Molecular Cell
30
(5),
pp. 620-631.
ISSN 1097-2765.
Remaut, Han and Tang, C. and Henderson, N.S. and Pinkner, J.S. and Wang, T. and Hultgren, S.J. and Thanassi, D.G. and Waksman, Gabriel and Li, H.L.
(2008)
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway .
Cell
133
(4),
pp. 640-652.
ISSN 0092-8674.
Salih, O. and Remaut, Han and Waksman, Gabriel and Orlova, Elena
(2008)
Structural analysis of the Saf pilus by electron microscopy and image processing .
Journal of Molecular Biology
379
(1),
pp. 174-187.
ISSN 0022-2836.
Allen, William J. and Rothwell, P.J. and Waksman, Gabriel
(2008)
An intramolecular FRET system monitors fingers subdomain opening in Klentaq1 .
Protein Science
17
(3),
pp. 401-408.
ISSN 0961-8368.
Rose, R.J. and Welsh, T.S. and Waksman, Gabriel and Ashcroft, A.E. and Radford, S.E. and Paci, E.
(2008)
Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics .
Journal of Molecular Biology
375
(4),
pp. 908-919.
ISSN 0022-2836.
Sauer, F.G. and Pinkner, J. and Waksman, Gabriel and Hultgren, S.J.
(2002)
Chaperone priming of pilus subunit facilitates a topological transition that drives fiber formation .
Cell
111
(4),
pp. 543-551.
ISSN 0092-8674.
Dodson, K.W. and Pinkner, J.S. and Rose, T. and Magnusson, G. and Hultgren, S.J. and Waksman, Gabriel
(2001)
Structural basis of the interaction of the pyelonephritic e. coli adhesin to its human kidney receptor .
Cell
105
(6),
pp. 733-743.
ISSN 0092-8674.
Sauer, F.G. and Fütterer, K. and Pinkner, J.S. and Dodson, K.W. and Hultgren, S.J. and Waksman, Gabriel
(1999)
Structural basis of chaperone function and pilus biogenesis .
Science
285
(5430),
pp. 1058-1061.
ISSN 0036-8075.
Korolev, S. and Hsieh, J. and Gauss, G.H. and Lohman, T.M. and Waksman, Gabriel
(1997)
Major domain swiveling revealed by the crystal structures of complexes of e. coli rep helicase bound to single-stranded DNA and ADP .
Cell
90
(4),
pp. 635-647.
ISSN 0092-8674.
Ornitz, D. and Herr, A. and Nillson, M. and Westman, J. and Svahn, C.-M. and Waksman, Gabriel
(1995)
FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides .
Science
268
(5209),
pp. 432-436.
ISSN 0036-8075.
Waksman, Gabriel and Shoelson, S. and Pant, N. and Cowburn, D. and Kuriyan, J.
(1993)
Binding of a high affinity phosphotyrosyl peptide to the src SH2 domain: crystal structures of the complexed and peptide-free forms .
Cell
72
(5),
pp. 779-790.
ISSN 0092-8674.
Waksman, Gabriel and Kominos, D. and Robertson, S. and Pant, N. and Baltimore, R. and Birge, D. and Cowburn, H. and Hanafusa, B. and Mayer, B. and Overduin, M. and Resh, M. and Rios, C. and Silverman, L. and Kuriyan, J.
(1992)
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides .
Nature
358,
pp. 646-653.
ISSN 0028-0836.
Book Section
Terradot, L. and Bergé, C. and Waksman, Gabriel
(2017)
Structural and molecular biology of Type IV Secretion Systems .
In: Backert, S. and Grohmann, E. (eds.)
Type IV Secretion in Gram-Negative and Gram-Positive Bacteria .
Current Topics in Microbiology and Immunology.
Springer.
pp. 31-60.
ISSN 0070-217X.
ISBN 9783319752402.
Allen, William J. and Phan, Gilles and Waksman, Gabriel
(2009)
Structural biology of periplasmic chaperones .
In: Eisenberg, D.S. and McPherson, A. (eds.)
Advances in Protein Chemistry and Structural Biology .
Maryland, U.S.: Academic Press Inc..
pp. 51-98.
ISBN 9780123748270.